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#1
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Insulin resistance, type 2 diabetes, atherosclerosis, poly cysticovarian syndrome, non-alcoholic fatty liver disease etc are increasing at analarming rate world over.
Insulin resistance, type 2 diabetes, atherosclerosis, poly cystic
ovarian syndrome, non-alcoholic fatty liver disease etc are increasing at an alarming rate world over. As there is no real cure for these diseases, prevention of management of these disorders is achieved successfully by life style interventions. To know how preventive measures will help to reduce or treat these disorders, we need to know some basic about these diseases. Fat feeding potentiates the diabetogenic effect of dexamethasone in Wistar rats Abstract Background The role of cortisol and its increased action/availability is implicated in the pathogenesis of insulin resistance associated with obesity and metabolic syndrome but the mechanism of increased action/ availability is not known. Availability of several other lipophilic hormones, drugs and pollutants are also reported to be increased in obesity. Increased lipids in the circulation are reported to alter the fluidity and permeability of membranes. Hyperlipidemia is also reported to alter the pharmacokinetics and pharmacodynamics of lipophilic molecules and also membrane fluidity and permeability. In this context we assumed that the hyperlipidemia associated with human obesity might play a role in the altered action/availability of cortisol and this in turn might have initiated the metabolic complications. To evaluate our assumption we have administered dexamethasone [low [50 ìg/kg/day] or high [250 ìg/kg/day] dose] to high-fat [coconut oil & vanaspati] fed rats and the results were compared with rats administered with either dexamethasone or high-fat. Results and Discussion Within two weeks, the rats co-administered with high-fat and dexamethasone developed severe hyperglycemia, hyperlipidemia and insulin resistance compared to rats treated either of them alone. High- fat fed rats treated with higher dose of dexamethasone were presented with severe hyperglycemia, insulin resistance and also severe glycosuria. The hyperlipidemia caused by high-fat feeding might have altered the transport and distribution of dexamethasone, probably by altering the physical state of membranes and transport proteins. Conclusion From the results obtained, it can be speculated that the altered lipid and cortisol metabolism could affect one another, forming a vicious cycle. Full text of the article at: http://www.intarchmed.com/content/1/1/7 |
#2
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Insulin resistance, type 2 diabetes, atherosclerosis, poly cystic ovarian syndrome, non-alcoholic fatty liver disease etc are increasing at an alarming rate world over.
"Rakshi" wrote Is this about cats or humans or what? |
#3
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Insulin resistance, type 2 diabetes, atherosclerosis, poly cysticovarian syndrome, non-alcoholic fatty liver disease etc are increasing at analarming rate world over.
On Mar 31, 8:08*pm, "cybercat" wrote:
"Rakshi" wrote Is this about cats or humans or what? this is based on research in rats. |
#4
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Insulin resistance, type 2 diabetes, atherosclerosis, poly cystic ovarian syndrome, non-alcoholic fatty liver disease etc are increasing at an alarming rate world over.
"Rakshi" wrote in message ... On Mar 31, 8:08 pm, "cybercat" wrote: "Rakshi" wrote Is this about cats or humans or what? this is based on research in rats. Why are you posting it in a cat group? |
#5
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Insulin resistance, type 2 diabetes, atherosclerosis, poly cystic ovarian syndrome, non-alcoholic fatty liver disease etc are increasing at an alarming rate world over.
"cybercat" wrote in message ... "Rakshi" wrote in message ... On Mar 31, 8:08 pm, "cybercat" wrote: "Rakshi" wrote Is this about cats or humans or what? this is based on research in rats. Why are you posting it in a cat group? Because he is an idiot |
#6
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Insulin resistance, type 2 diabetes, atherosclerosis, poly cysticovarian syndrome, non-alcoholic fatty liver disease etc are increasing at analarming rate world over.
On Mar 31, 9:53*pm, "Matthew"
wrote: "cybercat" wrote in message ... "Rakshi" wrote in message .... On Mar 31, 8:08 pm, "cybercat" wrote: "Rakshi" wrote Is this about cats or humans or what? this is based on research in rats. Why are you posting it in a cat group? Because he is an idiot No, it is a general information can to be extended to any life forms. |
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